Welcome to our comprehensive guide on MAXIDEX, a prescription-only medicine used for the treatment of various inflammatory conditions of the eye. In this article, we will provide detailed information about MAXIDEX, including its active ingredient, therapeutic indications, posology, contraindications, and more. Whether you are a healthcare professional or a patient seeking information about this medication, we've got you covered.
1. Name and Composition
MAXIDEX is the name of the medicinal product we will be discussing in this article. It is an eye drop suspension containing dexamethasone as its active ingredient. Each milliliter of MAXIDEX eye drops contains 0.1% w/v of dexamethasone. The suspension also contains benzalkonium chloride as an excipient.
2. Therapeutic Indications
MAXIDEX is indicated for the treatment of various steroid-responsive inflammatory conditions of the conjunctiva, cornea, and anterior segment of the eye. These conditions include anterior uveitis, iritis, cyclitis, allergic and vernal conjunctivitis, herpes zoster keratitis, superficial punctate keratitis, non-specific superficial keratitis, and corneal injury from chemical, radiation, thermal burns, or foreign bodies. It is also used post-operatively to reduce inflammatory reactions and suppress graft reaction .
3. Posology and Method of Administration
The frequency and duration of treatment with MAXIDEX eye drops may vary depending on the severity of the underlying condition and the response to treatment. In severe inflammations, one to two drops of MAXIDEX should be instilled into the eye every thirty to sixty minutes until a satisfactory response occurs. Subconjunctival or systemic steroid therapy should be considered if there is no response. Once a favorable response has been observed, the dosage should be reduced to one drop every four hours .
MAXIDEX eye drops are for ocular use only. Before using the eye drops, shake the bottle well. After removing the cap, make sure to remove any tamper-evident snap collar if it is loose. To administer the drops, avoid letting the tip of the dropper touch the eye. It is recommended to occlude the nasolacrimal duct or gently close the eyelid after administration to reduce systemic absorption and minimize adverse reactions .
4. Contraindications and Special Warnings
MAXIDEX eye drops are contraindicated in the following conditions:
- Vaccinia, varicella, or other viral diseases of the cornea and conjunctiva (except herpes zoster keratitis)
- Herpes simplex keratitis
- Fungal diseases of ocular structures or untreated parasitic eye infections
- Mycobacterial ocular infections
- Acute, untreated bacterial infections
- Hypersensitivity to dexamethasone or any of the excipients listed in section 6.1 of the product information.
Special warnings and precautions should be taken into account when using MAXIDEX eye drops. Prolonged use of topical ophthalmic corticosteroids, such as dexamethasone, may result in ocular hypertension, glaucoma, reduced visual acuity, visual field defects, and posterior subcapsular cataract formation. Routine checks of intraocular pressure and the lens should be performed, especially in patients with a history or presence of glaucoma. Corticosteroid-induced ocular hypertension may occur earlier and be greater in children. The risk of raised intraocular pressure and/or cataract formation is increased in predisposed patients, such as those with diabetes.
Other important warnings and precautions include:
- Topical corticosteroids should not be used for longer than one week without ophthalmic supervision.
- Prolonged or intensive therapy with ocular dexamethasone may cause Cushing's syndrome and/or adrenal suppression, particularly in predisposed patients or those receiving CYP3A4 inhibitors.
- Corticosteroids may reduce resistance to and aid in the establishment of bacterial, viral, fungal, or parasitic infections. In such cases, antibiotic therapy is mandatory.
- Topical ophthalmic corticosteroids may slow corneal wound healing. Concomitant use of topical NSAIDs and topical steroids may increase the potential for healing problems.
- In diseases causing thinning of the cornea or sclera, perforations have been known to occur with the use of topical corticosteroids.
- Visual disturbances may occur with systemic and topical corticosteroid use. Patients experiencing blurred vision or other visual disturbances should be referred to an ophthalmologist for evaluation.
- The wearing of contact lenses is discouraged during treatment with MAXIDEX. If contact lenses are used, they should be removed before applying the eye drops and reinserted at least 15 minutes later.
- Safety and efficacy of MAXIDEX in children under two years of age have not been established.
- In patients receiving systemic corticosteroids, new-onset or exacerbation of pre-existing diabetes mellitus may occur.
5. Undesirable Effects
The most common adverse reaction observed during clinical trials of MAXIDEX eye drops was ocular discomfort. Other reported adverse reactions include keratitis, conjunctivitis, dry eye, vital dye staining of the cornea, photophobia, blurred vision, eye pruritus, increased lacrimation, eye irritation, ocular hyperemia, glaucoma, ulcerative keratitis, increased intraocular pressure, reduced visual acuity, corneal erosion, eyelid ptosis, eye pain, and mydriasis. These adverse reactions are classified based on their frequency of occurrence.
6. Pharmacological Properties
Dexamethasone, the active ingredient in MAXIDEX eye drops, belongs to the pharmacotherapeutic group of ophthalmologicals: anti-inflammatory agents. It has been demonstrated to possess approximately six to seven times the potency of prednisolone and at least 30 times the potency of cortisone. Dexamethasone is rapidly absorbed after oral administration and can produce systemic effects when applied topically to the skin and eye. It is metabolized in the liver and excreted in the urine. Intraocular penetration of dexamethasone contributes to its effectiveness in treating anterior segment inflammatory diseases .
MAXIDEX eye drops, containing dexamethasone as the active ingredient, are used for the treatment of various steroid-responsive inflammatory conditions of the eye. It is important to follow the prescribed posology and method of administration, while also considering the contraindications, warnings, and precautions associated with the use of MAXIDEX. Adverse reactions may occur, and it is essential to be aware of them. If you have any questions or concerns about MAXIDEX, consult your healthcare professional for further guidance .
*Please note that this article is for informational purposes only and should not replace professional medical advice.